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KMID : 0364820210570010023
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Korean Journal of Microbiology
2021 Volume.57 No. 1 p.23 ~ p.29
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Molecular characterization of dengue virus isolated from patients in Gyeonggi-do
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Lee Hyun-Kyung
Moon Su-Kyong
Lee So-Hyun
Cho Han-Gil
Han Baek-Sang
Lee Han-Na
Moon Su-Jin
Kim Eun-Bee
Kim Young-Sug
Oh Jo-Gyo
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Abstract
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Dengue fever is an acute febrile illness infected by dengue virus, mediated by mosquitoes. To investigate the detection pattern, serotype and genotype distribution of dengue virus in Gyeonggi-do during 2016~2019, serums isolated from suspected patients who had oversea trip were collected and analyzed with RT-PCR. Dengue virus was detected in 111 cases (17.4%) from 638 samples. About 98.9% of dengue virus infections originated from endemic countries in Asia. Serotype was detected in order as DENV-2 (38.7%), DENV-1 (36.1%), DENV-3 (20.7%), and DENV-4 (4.5%). Genotype distribution of isolated dengue virus was analyzed by sequencing of the Envelope (E) region. Genotype analysis showed that dengue virus had a local specific genotype depending on visit-country, but no genetic variation occurred in the same serotype. This study suggests that genotype analysis of dengue virus be a useful tool for epidemiological investigation of dengue fever patients.
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KEYWORD
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dengue virus, genotype, phylogenetic analysis, sequence analysis, serotype
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